2 doctors weighed in:

What systems of the body are affected by Parkinson's disease?

2 doctors weighed in

In brief: Disease of misfolded

Proteins, affecting numerous neurotransmitters, especially a Dopamine deficit.
Main brain systems include basal ganglia (especially substantial nigra), but also dorsal vagal nucleus, locus ceruleous, and pallidum. But we are now finding areas of pathology in the gut (meissner's plexus), so this may be more systemic than we used to think.

In brief: Disease of misfolded

Proteins, affecting numerous neurotransmitters, especially a Dopamine deficit.
Main brain systems include basal ganglia (especially substantial nigra), but also dorsal vagal nucleus, locus ceruleous, and pallidum. But we are now finding areas of pathology in the gut (meissner's plexus), so this may be more systemic than we used to think.
Dr. Bennett Machanic
Dr. Bennett Machanic
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Dr. Gregg Friedman
Gregg L. Friedman MD Psychiatrist agrees
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