10 doctors weighed in:
Is it safe to cut a time release wellbutrin (bupropion) tablet in half?
10 doctors weighed in

Dr. Allen Fein
Family Medicine
6 doctors agree
In brief: Don't break these!
The active medication is contained in a special coating that permits delayed release of the therapeutic ingredients into the patient.
Breatking these tablets in half will release the active ingredient much faster than intended, probably bringing about unwanted side effects. Just not worth the gamble, especially when the generic form, buproprion, is safe, easily available, and better priced.

In brief: Don't break these!
The active medication is contained in a special coating that permits delayed release of the therapeutic ingredients into the patient.
Breatking these tablets in half will release the active ingredient much faster than intended, probably bringing about unwanted side effects. Just not worth the gamble, especially when the generic form, buproprion, is safe, easily available, and better priced.
Dr. Allen Fein
Dr. Allen Fein
Thank
Dr. Donald Hazlett
Psychiatry
2 doctors agree
In brief: Not a good idea
Cutting it destroys the timed release factor. It's not a good idea for that reason and because the effect of the split medication acting like regular release welbutrin(buproprion) is unpredictable when one has taken the extended release form. As a general rule, extended release medication should be left intact and med changes done by the prescribing professional.

In brief: Not a good idea
Cutting it destroys the timed release factor. It's not a good idea for that reason and because the effect of the split medication acting like regular release welbutrin(buproprion) is unpredictable when one has taken the extended release form. As a general rule, extended release medication should be left intact and med changes done by the prescribing professional.
Dr. Donald Hazlett
Dr. Donald Hazlett
Thank
Dr. Alan Ali
Psychiatry
1 doctor agrees
In brief: Wellbutrin (bupropion)
Agree. Also, general rule : never split slow-release or extended-release or long-acting medications.

In brief: Wellbutrin (bupropion)
Agree. Also, general rule : never split slow-release or extended-release or long-acting medications.
Dr. Alan Ali
Dr. Alan Ali
Thank
1 comment
Dr. Ralph Morgan Lewis
No, it is NOT safe. As Dr. Ali pointed out, never split time-release tabs/capsules; it defeats the purpose of their creation.
Dr. Alan Ali
Psychiatry
In brief: Slow release Wellbut
As a general rule, do not crush or break any slow-release or extended release medications.

In brief: Slow release Wellbut
As a general rule, do not crush or break any slow-release or extended release medications.
Dr. Alan Ali
Dr. Alan Ali
Thank
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