Currently take amitryptaline 10 mg nightly for migraines is it safe to take nyquil for a cold or will there be an adverse interaction between the two?

Caution is advised. There is a drug to drug interaction between the 2 agents. The combination may increase the risk of CNS depression, psychomotor impairment, and anticholinergic adverse effects (additive effects). Hence, i would advise against the use of the 2 agents concomitantly.