What makes ant bites itch?

Histamine. Ants release a chemical called formic acid when they bite. As this is an irritant, our bodies release histamine at the site of the bite which causes itchiness.
Histamine. Bug bites tend to itch because they leave behind some extra saliva or other products from their biting apparatus. These substances are recognized as foreign material by your body, which mounts an inflammatory response to mobilize cleanup and infection control. A key component is histamine, which increases flow to that area (red welt) and itches. Histamine is the same stuff that causes hives.
Skin reaction. The chemicals from the bites of ants cause a reaction in your skin, which causes the itching. Medications, like diphenhydramine, (benadryl in the US) block part of this reaction and can provide relief. Corticosteroids (like hydrocortisone) applied to the skin can also block another part and provide relief as well.

Related Questions

Red spot size of quarter upper thigh inch below ant bites couple of inches above where I do a shot for methotrexate every week! Itches and hurts?

Red skin lesion. Without a picture, it is difficult to say. Is the spot uniform, of]R does it look like a "target?" Is it flat, or raised? While it could represent a reaction to the ant bites, the proximity to your injection site is worrisome. I would bring it to the attention of your treating physician. . Read more...

Why does itching an ant bite feel so good?

Stimulant. Everytime you scratch any itch, you are either a-removing the irritant b- stimulating the blood flow to the area which moves the histamine which is causing the itch. Read more...

What's the best way to prevent itching on a mosquito or ant bite?

Topical steroid. 1% hydrocortisone cream applied locally can often relieve itching. No systemic drowsiness effects. Thanks for trusting HealthTap! Read more...
You can. Utilize many nonprescription tools; most are benign and may or may not work for you but consider cold packs, or cold steeped tea bags, homemade baking soda paste, over-the-counter benadryl (diphenhydramine) cream or calamine lotion or nonprescription strength hydrocortisone cream. Read more...