Gf has took some antibiotics and feels like needs to be sick. Will they work if she does be sick? Took them at 10:30 current time 12:35

Possibly. Without more detailed information it is difficult to respond definitively, but if she threw up shortly after taking the medication she may need to take it again. The other question is whether she was reacting to the meds or her illness was causing the nausea and vomiting. You might want to call her doctor and check for their input.