1 doctor weighed in:

Can you take a night time sleep-aid diphenhydramine with 24 hour zyrtec (cetirizine) equivalent in your system?

1 doctor weighed in
Dr. Michael Zacharisen
Internal Medicine - Allergy & Immunology

In brief: Yes, but caution

Zyrtec (cetirizine) is a minimal sedating antihistamine while Diphenhydramine (benadryl) is a first generation antihistamine with significant drowsy side effects.
There may be carry over effect from diphenhydramine. Avoid drinking alcohol. Consider another sleep aid if this is a persistent problem.

In brief: Yes, but caution

Zyrtec (cetirizine) is a minimal sedating antihistamine while Diphenhydramine (benadryl) is a first generation antihistamine with significant drowsy side effects.
There may be carry over effect from diphenhydramine. Avoid drinking alcohol. Consider another sleep aid if this is a persistent problem.
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