What are the long terms psychological effects of medications used to treat depression?

L-T Effects. In some people, memory problems, diminished concentration, and fatigue can persist while you are on the medication.
Varies. Medical depressive disorder is a neurobiochemical disorder affecting certain chemical connections and parts of brain. Antidepressants (ad) correct these defects in many patients. The long term psychological consequences are therefore good ones (as shown in many research studies). Adverse effects do occur with ad's but are mostly reversible. In bipolar patients ad's can trigger mania.