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What are possible reasons for normal cortisol levels in the blood but high levels in the urine?
3 doctors weighed in

Dr. Maritza Baez
Family Medicine
2 doctors agree
In brief: Need More tests
A single blood sample may not accurately reflect cortisol levels as peak values may have occurred at a different point during the daily cycle, producing a normal blood sample when cortisol levels are actually elevated.
The elevation would be detected, however, by 24-hour urine cortisol levels. High urine cortisol can be caused by cushing's, lung cancer, adrenal tumors.

In brief: Need More tests
A single blood sample may not accurately reflect cortisol levels as peak values may have occurred at a different point during the daily cycle, producing a normal blood sample when cortisol levels are actually elevated.
The elevation would be detected, however, by 24-hour urine cortisol levels. High urine cortisol can be caused by cushing's, lung cancer, adrenal tumors.
Dr. Maritza Baez
Dr. Maritza Baez
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