Do antihistamines cause gout?

Typically no

Leg
Antihistamines are generally not considered a group of medications that directly cause gout. However, antihistamines can cause dryness, and if that progresses to dehydration, then gout attacks can occur with a higher frequency. This would be an indirect cause. Antihistamines generally don't cause significant dehydration. Aspirin can make gout worse, as can other salicylate-containing meds.
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Gout Dehydration Antihistamine Aspirin Benadryl Oral antihistamine

No

Antihistamines
Antihistamines do not cause gout.
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Gout Antihistamine Benadryl Oral antihistamine