What is the best way to handle jet lag? Is there a difference for east- and westbound travel? L

Maybe. melatonin may help a little. here are other suggestions: http://sleepfoundation.org/sleep-topics/jet-lag-and-sleep.
Plan accordingly. There is a difference between eastward and westward travel. It is generally easier to accommodate to travel west... We just adjust our schedules accordingly. Travel east is usually more difficult... Travel across 2 or more time zones usually requires about a day/time zone to adjust. Exposure to bright sunlight is the best method for adjusting to jet-lag.