Need more info. Totally different genes predispose to colon cancer, including BRCA 1 and 2; Familial Adenomatous Polyposis develops so many polyps in the colon they may be too numerous to count--but this one is quite rare. The commonest is Hereditary Non-Polyposis Colon Cancer. You may be at increased risk if close family members have developed it. See http://www. Hopkinscoloncancercenter. Org/CMS/CMS_Page. Aspx?
HNPCc. Hereditary nonpolyposis colorectal cancer.
Not so simple. There are a few genes we test for now for familial colon cancer: fap, msh-1/mlh-2, myh. .. But you can't simply get tested out of the blue. A family member with the colon cancer has to be first tested. If any of those genes are found, then the relatives are tested for those specific genes.
Not really. While there are certain genetic abnormalities that will help your doctor determine a course of treatment, as of yet there is no prognostic profile for colon cancer that is in general use.
Yes. A test called oncotype DX can help predict the behavior of colon cancer and likelihood of it coming back. Visit: www. Oncotypedx. Com.
Planning. Not everyone wants to know about a risk for cancer. However knowing about colon cancer risk allows you to get a colonoscopy every year to check for cancer before it grows. Also it allows you to have a discussion with a surgeon about your options to remove the colon before it affects you. This can be life saving. There are different genes for colon cancer risk and they have different implications.
Allows. You to get more frequent screening exams and early diagnosis resulting in better outcomes and survival. Also relates to your childrens risk of developing colon cancer.
Depends. Family history and thus genes can account for approximately 20% of all colon cancers.
Lynch syndrome. Genetic risk is definite risk for early colorectal cancer.
Grandfather had colon cancer at 87, uncle had noncancerous polyps at 48. Mother has no polyps. Likely a colon cancer gene?
Likely Not. You have to have three or more family members with a confirmed diagnosis of colorectal cancer, one of whom should be a first degree (parent, child, sibling) relative.
Probably no. Not a terribly impressive cancer history but in my experience, both patients and docs could do a much better job when getting a thorough family history. If you are concerned, get all the family info you can (members with any and all cancers and even those without) and visit with your doc. I've told patients to do that and occasionally get a surprise.
Probably not. All cancer is a genetic disease in some way but if you mean did you inherit a gene that causes cancer, then this history, as bad as it may seem, is fairly common. To suspect a genetic predisposition to cancer of the colon, you would need more than one grandfather effected, actually several family members. But colon cancer is common and everyone, including you, needs screening in their 50's.
Yes, BUT. There are commercial tests available. They are not more effective than other methods of screening (fecal occult blood and colonoscopy) and are not as cost effective.
Yes and no. Most colon cancers occur from random dna mutations. Most of these are fixed by your body's immune system. Some families will have an inherited gene that makes colon cancer more likely. In these families colon cancer affects multiple family members or at an early age. Unless there is any evidence of inherited genes there is no good reason to check for them. Colonoscopy starting age 50 is best.
Are the people with family history/genetic factors the only ones who have colon cancer in their lower twenties?
No. The prevalence of identifiable genetic risk factors much higher among young people who get colon cancer. However, not all such young people have identifiable genetic risk factors. It's likely that many genetic abnormalities leading to cancer have not yet been discovered.