2 doctors weighed in:

Is edward's syndrome autosomal or sex-linked? Dominant or recessive?

2 doctors weighed in
Dr. James Ferguson
Pediatrics
1 doctor agrees

In brief: None of the above

Edward syndrome is brought on by an abnormality of chromosome numbers, specifically an extra 18.
The abnormal egg with a single chromosome 1-17 & 19-22 + x has a pair of 18's. When the sperm brings a single chromosome 1-22 + x or y then the embryo ends up with 47 chromosomes rather than 46 in every cell.(3-18's) the excess distorts the organ building information & defects arise.

In brief: None of the above

Edward syndrome is brought on by an abnormality of chromosome numbers, specifically an extra 18.
The abnormal egg with a single chromosome 1-17 & 19-22 + x has a pair of 18's. When the sperm brings a single chromosome 1-22 + x or y then the embryo ends up with 47 chromosomes rather than 46 in every cell.(3-18's) the excess distorts the organ building information & defects arise.
Dr. James Ferguson
Dr. James Ferguson
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Dr. Johanna Fricke
Pediatrics - Developmental & Behavioral

In brief: Trisomy 18

When egg & sperm meet, their chromosomes split so 1/2 of dad's & 1/2 of mom's can join.
The chromosome 18 in either egg or sperm divided unequally, & part or all of both chr.18's pair up with one chr. 18 from the other parent. A full or partial trisomy, (3 chr. 18's, ) occured by accident. Abnormal formation of the heart & other organs, intellectual disability & unusual facial features result.

In brief: Trisomy 18

When egg & sperm meet, their chromosomes split so 1/2 of dad's & 1/2 of mom's can join.
The chromosome 18 in either egg or sperm divided unequally, & part or all of both chr.18's pair up with one chr. 18 from the other parent. A full or partial trisomy, (3 chr. 18's, ) occured by accident. Abnormal formation of the heart & other organs, intellectual disability & unusual facial features result.
Dr. Johanna Fricke
Dr. Johanna Fricke
Thank
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