NSAID's. Nsaid's such as Ibuprofen are typically the first medication to try. If low occasional doses of Ibuprofen don't do the trick, you really need to see a dentist about a bite splint (something to wear at night). I typically use an 'anterior bite plane' 24x7 for 2 weeks with a steroid for the first week. After this, the buite guard goes to nighttime use only. This does the trick in 99% of cases.
Depends on the cause. Meds and surgery should be the last lines of defense for tmj/tmd, it depends on what treatment you have already had, if any, and the degree of success of the treatment. Should see a dentist or specialist before depending on meds. The source of the problem is imperative!