Not good news. There are no great prescription medications out there. There are concerns that meridia, phentermine, etc. Have too many risks and studies have shown that they are minimally, if at all, effective. There is no substitute for burning more calories than you consume. My patients have had some success with alli, which is otc. Good luck!
Weight med. As a practicing bariatrician for over 15 years, the most effective weight medication available is phentermine. It is about 60 years on the market. In experienced physicians' practices the weight loss averages 10-15 % of weight lost. The key is the physician's monitoring of the patient usually monthly. The patient must be thoroughly evaluated by a physician who subspecializes in weight management.