3 doctors weighed in:
Why does the rickettsia test exist if it isn't accurate or accepted?
3 doctors weighed in

Dr. Lori Wagner
Internal Medicine
1 doctor agrees
In brief: Complicated answer
Even when tests are highly sensitive and specific, how well they can tell a patient if they have the disease or not (positive and negative predictive value) is highly dependent upon the prevalence of the disease.
Tests such as this are useful only if the clinical situation supports the diagnosis (we call this pre-test probability).

In brief: Complicated answer
Even when tests are highly sensitive and specific, how well they can tell a patient if they have the disease or not (positive and negative predictive value) is highly dependent upon the prevalence of the disease.
Tests such as this are useful only if the clinical situation supports the diagnosis (we call this pre-test probability).
Dr. Lori Wagner
Dr. Lori Wagner
Thank
Dr. Larry Lutwick
Internal Medicine - Infectious Disease
In brief: Depends on the test.
If the test is one of the old weil-felix tests for rickettsial disease which rely on cross-reacting antibody between certain strains of the bacterium proteus and certain rickettsia, they are worthless in today's world.
The more modern antibody tests for rickettsia are better, more sensitive if done properly but still some crossreactivity with other rickettsiae.

In brief: Depends on the test.
If the test is one of the old weil-felix tests for rickettsial disease which rely on cross-reacting antibody between certain strains of the bacterium proteus and certain rickettsia, they are worthless in today's world.
The more modern antibody tests for rickettsia are better, more sensitive if done properly but still some crossreactivity with other rickettsiae.
Dr. Larry Lutwick
Dr. Larry Lutwick
Thank
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