Probably. While any drug taken during pregnancy has the potential to negatively affect the fetus, calcineurin inhibitors like tacrolimus and pimecrolimus are considered category c drugs, which means that they have not been associated with fetal loss or birth defects in animal studies. However, category c also means that these drugs have not been well studies in humans, so there may be potential risks.
Unknown. Category c, unknown risk in humans during pregnancy or breast feeding. Animal studies have suggested risks. It is a topical drug but common side effects suggest absorbtion. Risk will have to be weighed against benefits by the patient and her doctor.