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How does isosorbide dinitrate or mononitrate help prevent angina attacks?

3 doctors weighed in
Dr. Alon Gitig
Internal Medicine - Cardiology
1 doctor agrees

In brief: Supply and demand

Angina is caused by heart muscle not getting enough blood to meet its needs, think supply vs demand.
By relaxing smooth muscle in the walls of coronary arteries, nitrates increase blood flow. They also dilate the body's veins, so less blood returns to the heart, and the heart walls are less stretched outwards. This reduces tension on the heart wall muscle, and hence demand for oxygen/blood.

In brief: Supply and demand

Angina is caused by heart muscle not getting enough blood to meet its needs, think supply vs demand.
By relaxing smooth muscle in the walls of coronary arteries, nitrates increase blood flow. They also dilate the body's veins, so less blood returns to the heart, and the heart walls are less stretched outwards. This reduces tension on the heart wall muscle, and hence demand for oxygen/blood.
Dr. Alon Gitig
Dr. Alon Gitig
Thank
Dr. Louis Grenzer
Internal Medicine - Cardiology

In brief: Dilates arteries

The nitroglycerine dilates the coronary arteries.
By relaxing the smooth muscle in the arteries, the medicine increases the diameter of the artery allowing greater blood flow.

In brief: Dilates arteries

The nitroglycerine dilates the coronary arteries.
By relaxing the smooth muscle in the arteries, the medicine increases the diameter of the artery allowing greater blood flow.
Dr. Louis Grenzer
Dr. Louis Grenzer
Thank
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