8 doctors weighed in:

Can naltrexone cause liver damage?

8 doctors weighed in
Dr. Jeff Blixt
Addiction Medicine
3 doctors agree

In brief: Yes

There is a risk of liver damage, this risk is increased with preexisting liver problems or very high doses of the med.
Usually your doctor will make that assessment and monitor your liver enzymes before and while you are on it. Properly monitored the risk is low.

In brief: Yes

There is a risk of liver damage, this risk is increased with preexisting liver problems or very high doses of the med.
Usually your doctor will make that assessment and monitor your liver enzymes before and while you are on it. Properly monitored the risk is low.
Dr. Jeff Blixt
Dr. Jeff Blixt
Thank
Dr. Mark Shukhman
Addiction Medicine
1 doctor agrees

In brief: Generally, no

as far as I know, liver problems were even removed from the package insert.
It happened in high doses: 300 – 400 mg per day. The patients who had problems were also taking other medications. My answer is to the best of my knowledge. Of course, from the medical legal standpoint I have to tell you that you have to follow the information on the package insert. What are taking naltrexone for?

In brief: Generally, no

as far as I know, liver problems were even removed from the package insert.
It happened in high doses: 300 – 400 mg per day. The patients who had problems were also taking other medications. My answer is to the best of my knowledge. Of course, from the medical legal standpoint I have to tell you that you have to follow the information on the package insert. What are taking naltrexone for?
Dr. Mark Shukhman
Dr. Mark Shukhman
Thank
Dr. Mark Reynolds
Psychiatry
1 doctor agrees

In brief: Rarely

It is my understanding that the elevations in liver enzymes reported with Naltrexone primarily occurred in trials done for eating disorders/obesity.
In these trials the medication was being tested up to 350 mg daily, 7x the usual dose. The likelihood of any significant adverse event involving the liver at commonly prescribed doses is very, very low.

In brief: Rarely

It is my understanding that the elevations in liver enzymes reported with Naltrexone primarily occurred in trials done for eating disorders/obesity.
In these trials the medication was being tested up to 350 mg daily, 7x the usual dose. The likelihood of any significant adverse event involving the liver at commonly prescribed doses is very, very low.
Dr. Mark Reynolds
Dr. Mark Reynolds
Thank
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