5 doctors weighed in:
How long does it take naloxone to get out of my system?
5 doctors weighed in

Dr. Joseph De santi
Family Medicine
2 doctors agree
In brief: Nifty Naloxone
Naloxone, or Narcan (naloxone) is intended to reverse narcotic overdose and is usually given in the vein, muscle or breathing tube (in emergencies).
It has a very rapid onset of action but a short life in the body. It's half life is 64 minutes, which means in approximately 4 hours it is completely out of the body primarily through the kidneys. Diminished kidney function could prolong the drug effect.

In brief: Nifty Naloxone
Naloxone, or Narcan (naloxone) is intended to reverse narcotic overdose and is usually given in the vein, muscle or breathing tube (in emergencies).
It has a very rapid onset of action but a short life in the body. It's half life is 64 minutes, which means in approximately 4 hours it is completely out of the body primarily through the kidneys. Diminished kidney function could prolong the drug effect.
Dr. Joseph De santi
Dr. Joseph De santi
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1 comment
Dr. Arthur Heller
The drugs it reverses may have a longer half life than the naloxone, so it is possible to wake up, then zonk out again after the effects of naloxone wear off
Dr. Alan Wartenberg
Addiction Medicine
1 doctor agrees
In brief: 20-30 minutes
Naloxone is short acting.
When given intravenously, it lasts 20-30 minutes; if it is given by nasal spray, takes a little longer to kick in (minutes instead of seconds) but lasts a little longer, perhaps up to an hour. Since many opiates are longer acting than that (esp Methadone and oxycontin), an od can recur after the Naloxone wears off. Naloxone is not tested for in most drug testing.

In brief: 20-30 minutes
Naloxone is short acting.
When given intravenously, it lasts 20-30 minutes; if it is given by nasal spray, takes a little longer to kick in (minutes instead of seconds) but lasts a little longer, perhaps up to an hour. Since many opiates are longer acting than that (esp Methadone and oxycontin), an od can recur after the Naloxone wears off. Naloxone is not tested for in most drug testing.
Dr. Alan Wartenberg
Dr. Alan Wartenberg
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