Is it safe to mix cocaine with ecstasy or other party drugs?

Very Unsafe. Both Cocaine and ecstasy can stimulate. Too much ecstasy can cause palpitations, chest pain, heart attack, heart failure, pulmonary hypertension, stroke, be toxic to the heart, angina pectoris, destruction of blood vesselscoma, organ failure, coma and death. I wouldn't add Cocaine to that mix. All of these drugs are dangerous - in combination even worse!
NO!!!! It's not safe to use cocaine! It's not safe to use ecstasy or other party drugs! What would make anybody think they are safe together? Most kids using ecstacy stop by their early 20s; if you are talking about yourself, or someone your age, you are engaging in behaviors that as dangerous as they are in younger people, are even more dangerous in those approaching 40, with older hearts and brain.