Antabuse (disulfiram) and wine. It should be okay to cook with a little wine while on antabuse (disulfiram). Most of the alcohol evaporates during cooking. If you take 250 mgs per day, or less, a very small amount of alcohol should not cause an Antabuse (disulfiram) reaction. Some take 500 mgs per day, and for those people, i would probably avoid any and all alcohol, even a small amount used for cooking. Good luck.