6 doctors weighed in:

Does my child have to inherit the same exact mutation from both parents in order to develop cystic fibrosis?

6 doctors weighed in
Dr. Brian Bezack
Pediatrics - Pulmonology
3 doctors agree

In brief: No

You need 2 mutations to inherit cf, but they can be, and often are, 2 different mutations.
The type of mutation can have an impact on the severity of the disease and the child's prognosis.

In brief: No

You need 2 mutations to inherit cf, but they can be, and often are, 2 different mutations.
The type of mutation can have an impact on the severity of the disease and the child's prognosis.
Dr. Brian Bezack
Dr. Brian Bezack
Thank
Dr. HARRY OPSIMOS
Pediatrics - Pulmonology
1 doctor agrees

In brief: No

Cystic fibrosis has been associated with over 1500 mutations.
A person does not need to have the exact same 2 mutations inherited to have the disease. A CF patient can have 2 different mutations inherited from the parents. The extent of the disease may depend on what mutations a person has, but also varies from one patient to another even with the same mutations. Other factors play a role as well.

In brief: No

Cystic fibrosis has been associated with over 1500 mutations.
A person does not need to have the exact same 2 mutations inherited to have the disease. A CF patient can have 2 different mutations inherited from the parents. The extent of the disease may depend on what mutations a person has, but also varies from one patient to another even with the same mutations. Other factors play a role as well.
Dr. HARRY OPSIMOS
Dr. HARRY OPSIMOS
Thank
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