3 doctors weighed in:

Do both parents have to be cystic fibrosis carriers in order for their child to be born with this disease?

3 doctors weighed in
Dr. HARRY OPSIMOS
Pediatrics - Pulmonology
1 doctor agrees

In brief: Yes

Both parents have to be carriers and then their child has 25% chance of having the disease, 50% chance of being a carrier and 25% of not even being a carrier. The most common mutation causing cystic fibrosis is ?f508.
But there are over 1500 mutations identified so far.

In brief: Yes

Both parents have to be carriers and then their child has 25% chance of having the disease, 50% chance of being a carrier and 25% of not even being a carrier. The most common mutation causing cystic fibrosis is ?f508.
But there are over 1500 mutations identified so far.
Dr. HARRY OPSIMOS
Dr. HARRY OPSIMOS
Thank
Dr. James Ferguson
Pediatrics

In brief: Yes

The gene for CF has been well characterized over the years and the delta 509 mutation represents the most prevalent.
If both unaffected parents carry this mutation they have a relative risk of 1/4 of creating a baby with CF with any conception.(2/4 carrier, 1/4 nl) there are other CF mutations & of parents carry a different mutation (one 509 & one another) the intensity of symptoms can vary.

In brief: Yes

The gene for CF has been well characterized over the years and the delta 509 mutation represents the most prevalent.
If both unaffected parents carry this mutation they have a relative risk of 1/4 of creating a baby with CF with any conception.(2/4 carrier, 1/4 nl) there are other CF mutations & of parents carry a different mutation (one 509 & one another) the intensity of symptoms can vary.
Dr. James Ferguson
Dr. James Ferguson
Thank
1 comment
Dr. HARRY OPSIMOS
ΔF508 is the name of the most common CF mutation
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