7 doctors weighed in:

How could 2 people without sickle-cell anemia to have a child with sickle-cell disease?

7 doctors weighed in
Dr. Joseph Torkildson
Pediatrics - Hematology & Oncology
2 doctors agree

In brief: Genetics

Sickle cell disease must be inherited from both parents.
Sickle cell trait (1 sickle gene, 1 normal gene) is usually asymptomatic. 2 persons with sickle cell trait have a 1/4 chance of having a child with sickle cell disease, but the parents are often unaware that they have anything.

In brief: Genetics

Sickle cell disease must be inherited from both parents.
Sickle cell trait (1 sickle gene, 1 normal gene) is usually asymptomatic. 2 persons with sickle cell trait have a 1/4 chance of having a child with sickle cell disease, but the parents are often unaware that they have anything.
Dr. Joseph Torkildson
Dr. Joseph Torkildson
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Dr. Scott Adams
Pediatrics - Hematology & Oncology
1 doctor agrees

In brief: Parents have trait

One biological parent would need to have sickle cell trait and the other biological parent would need to have sickle cell trait/ hemoglobin c trait/ or a form of beta thalassemia trait - depending upon the type of sickle cell disease.

In brief: Parents have trait

One biological parent would need to have sickle cell trait and the other biological parent would need to have sickle cell trait/ hemoglobin c trait/ or a form of beta thalassemia trait - depending upon the type of sickle cell disease.
Dr. Scott Adams
Dr. Scott Adams
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Dr. James Ferguson
Pediatrics
1 doctor agrees

In brief: Each carries S Trait

Recessive disorders are so named because they are not expressed unless two genes of the same type are carried in the chromasomes.
Dominedt genes can show up when only one gene is present. Sickle cell requires 2 recessive genes, one from each unaffected parent. Prenatal testing and genetic counseling are encouraged for populations at risk.

In brief: Each carries S Trait

Recessive disorders are so named because they are not expressed unless two genes of the same type are carried in the chromasomes.
Dominedt genes can show up when only one gene is present. Sickle cell requires 2 recessive genes, one from each unaffected parent. Prenatal testing and genetic counseling are encouraged for populations at risk.
Dr. James Ferguson
Dr. James Ferguson
Thank
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