6 doctors weighed in:

How is a baby born with the sickle cell trait when neither parents has it?

6 doctors weighed in
Dr. Roy Benaroch
Pediatrics
3 doctors agree

In brief: New mutation

Sickle cell trait is almost always caused by a gene passed down from one parent.
The parent may not even know he or she has it. Rarely, a new mutation can also occur-- a child's gene changes on its own, meaning that they didn't get it from a parent. I could not find the exact rate of these new mutations. It's rare, but it can at least theoretically happen.

In brief: New mutation

Sickle cell trait is almost always caused by a gene passed down from one parent.
The parent may not even know he or she has it. Rarely, a new mutation can also occur-- a child's gene changes on its own, meaning that they didn't get it from a parent. I could not find the exact rate of these new mutations. It's rare, but it can at least theoretically happen.
Dr. Roy Benaroch
Dr. Roy Benaroch
Thank
Dr. James Ferguson
Pediatrics
1 doctor agrees

In brief: New Mutation???

In theory, a new mutation where the instruction is changed in the gene sometime after conception.
I could find no data on frequency of such a possibility. It is more likely one of the parents carries the gene and is not aware of it. Trait seldom causes any issues and ~1/10 afro-americans carry the gene. Neither parent needs to have full blown ss disease to pass trait.

In brief: New Mutation???

In theory, a new mutation where the instruction is changed in the gene sometime after conception.
I could find no data on frequency of such a possibility. It is more likely one of the parents carries the gene and is not aware of it. Trait seldom causes any issues and ~1/10 afro-americans carry the gene. Neither parent needs to have full blown ss disease to pass trait.
Dr. James Ferguson
Dr. James Ferguson
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