What does it mean to have exocrine pancreatic insufficiency?

Digestive Enzymes. The pancreas' main exocrine function is to produce enzymes which help digest carbs, protein, and fats. These enzymes are made in acinar cells and travel down a duct to the small intestine (2nd stage of duodenum). Insufficiency can either be from an obstruction in said duct or a decreased synthesis of the enzymes from damage or fibrosis of pancreatic tissue, most commonly secondary to pancreatitis.
Pancreatic insuff. This means that the pancrease (pancrelipase) is not producing enough enzymes to help digest your food appropriately. This function of the pancreas is separate from the endocrine function of producing Insulin that is involved in glucose utilization in the body.