9 doctors weighed in:

Is it possible for liver cancer tumors to be too big for a transplant?

9 doctors weighed in
3 doctors agree

In brief: Milan criteria

Most transplant programs adhere to some form of the milan criteria that restrict transplants to persons with one tumor<5 cm, up to 3 tumors<3cm, no extrahepatic disease, and no vascular invasion.
Size is a marker for vascular invasion. Some programs have adjusted these criteria. Some tumors not amenable to transplant may nevertheless be resected (removed) surgically.

In brief: Milan criteria

Most transplant programs adhere to some form of the milan criteria that restrict transplants to persons with one tumor<5 cm, up to 3 tumors<3cm, no extrahepatic disease, and no vascular invasion.
Size is a marker for vascular invasion. Some programs have adjusted these criteria. Some tumors not amenable to transplant may nevertheless be resected (removed) surgically.
Dr. Debashish Bose
Dr. Debashish Bose
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Dr. Richard Mangus
Surgery - Transplant
2 doctors agree

In brief: Try to shrink tumors

Transplant is the best treatment for certain liver cancers.
Though all centers have criteria for acceptable tumor size in liver transplantation, there are mechanisms to improve the chances of approval for transplant. Liver directed therapy can be used to shrink tumors - embolization, radiation, etc. If they shrink, you may be reconsidered for transplant at some centers if within criteria.

In brief: Try to shrink tumors

Transplant is the best treatment for certain liver cancers.
Though all centers have criteria for acceptable tumor size in liver transplantation, there are mechanisms to improve the chances of approval for transplant. Liver directed therapy can be used to shrink tumors - embolization, radiation, etc. If they shrink, you may be reconsidered for transplant at some centers if within criteria.
Dr. Richard Mangus
Dr. Richard Mangus
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1 comment
Dr. Aaron Shiloh
There are several studies that have shown promise for patients to be downstaged to transplantation with y90 Therasphere.
Dr. Edward Gold
Internal Medicine
1 doctor agrees

In brief: Yes

According to the current tnm/uicc staging system for hepatocellular carcinoma most consider stages iiib, iiic, and stage iva, as well as stage ivb, disease to be incurable by resection.

In brief: Yes

According to the current tnm/uicc staging system for hepatocellular carcinoma most consider stages iiib, iiic, and stage iva, as well as stage ivb, disease to be incurable by resection.
Dr. Edward Gold
Dr. Edward Gold
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