What differentiates primary biliary cirrhosis from other types of cirrhosis?

Location of inflam. Agree with dr. Edmisson. Pbc is autoimmune disease affecting bile ducts; can eventually lead to progressive liver disease and cirrhosis (scarring). Othe types of cirrhosis usually involve inflammation of the liver cells, due to infection (like hep b, c), toxic chemicals, metabolic disease e.g.Nonalcoholic fatty liver (seen in obesity, diabetes) iron overload, damage from alcohol, autoimmune.
Origin of disease. Primary biliary cirrhosis (pbc) is a disease of the bile ducts within the liver, rather than a disease of the liver itself. The bile ducts become inflamed and scar over time, which eventually leads to the development of cirrhosis. Ursodiol can delay this progression of disease, but sometimes a liver transplant is warranted.

Related Questions

Is primary biliary cirrhosis hereditary?

Basically no. There's a pair of genes that carry the ability to develop the disease and these run in families, but it's not inherited like sickle cell, huntington's or some of the other familiar entities. http://www.medicalnewstoday.com/releases/151640.php. Read more...

What exactly is primary biliary cirrhosis?

Liver disease. Primary biliary cirrhosis is an autoimmune liver disease seen most commonly in women in the 4th to 5th decade of life. It generally presents with unexplained itching and occasionally jaundice. It is frequently found on routing screening liver tests which may show an elevated alkaline phosphotase. Though not curable it is treatable and treatment slows the progression to cirrhosis. Read more...
An inherited disease. Primary biliary cirrhosis is a condition of unknown cause with genetic predisposition, probably of an autoimmune nature, where the cells that line the biliary tract proliferate and eventually die and scarring occurs, which is what cirrhosis is about - scarring in the liver that interferes with its function. Definitive treatment is transplantation, but there are medications which can improve it. Read more...

How can I treat primary biliary cirrhosis?

Ursodiol. There is not much available to treat primary biliary cirrhosis, but ursodiol helps normalize the liver enzymes. For other therapies you should discuss with a hepatologist. Read more...

What can be done for primary biliary cirrhosis?

Number of things. If caught early, there are medications, particularly ursodeoxycholic acid (actigall) which can slow it down. Preventing and treating complications is also important, especially high pressure in the portal vein, which can be treated with beta blockers (inderal (propranolol) and others) and sometimes surgery. Itching, fatigue and other symptoms can be treated as well, but liver transplant is needed when severe. Read more...

Can you tell me about primary biliary cirrhosis?

Liver disease. Chronic disease of the liver from scarring of the biliary ducts. Probably an autoimmune disease. There are medications to help with this disease, but you need close follow up with a GI doc. Good luck. Read more...

What can I expect if I have primary biliary cirrhosis?

Progressive ldisease. Usually fatigue, jaundice, itching and development of ascites or leg edema. You should also screen for development of liver cancer. Read more...
Maybe liver failure. Primary biliary cirrhosis is an insidious disease that tends to be progressive over time. The small ducts that drain bile from the liver will narrow and prevent adequate drainage of bile to the intestine. The liver will experience damage with years of inadequate bile drainage and eventually severe scarring (cirrhosis) occurs. With cirrhosis, the only option is liver transplantation for best chance. Read more...

Has anyone survived primary biliary cirrhosis for long?

Yes. There are some new medications that have been effective for stopping the progression of primary biliary cirrhosis, particularly urso- deoxycholic acid. In addition, liver transplanation can be lifesaving, and patients can live normal lifespans after liver transplantation, although the need for anti- rejection drugs can affect the quality of life and cause complications which shorten life as well. Read more...

How does one effectively treat primary biliary cirrhosis?

Not a great answer . Unfortunately, there is no cure. The autoimmune disorder destroys the liver over time. The treatments help to relieve the symptoms (ursodiol, anti-itching meds, anti-inflammatory meds, immune suppressing meds etc.) and if the disease progresses to final stages, liver transplant is the only really treatment. Read more...