Is there a known cause of cholangiocarcinoma?

Risk factors. The following is a partial list of conditions that some studies (but not necessarily all) have found to be associated with an increased risk for cholangiocarcinoma (cancer of bile ducts).Chronic liver disease (eg from hepatitis C or alcohol), gallstones, hepatolithiasis (liver stones), primary sclerosing cholangitis, liver fluke infection, obesity, diabetes, congenital bile duct cysts, others...
Many hidden... Chronic liver disease due to hepatitis b or c leading to cirrhosis, [7] alcoholic liver disease, nonspecific cirrhosis, bile duct diseases (e.g., bile duct adenoma, biliary papillomatosis, and congenital liver abnormalities such as choledochal cyst and caroli disease), [8] [9] chronic typhoid carriers, infection with chlonorchis sinensis and opisthorchis, heavy drinking. Cholangioca is diff 2 dx.