What is the significance of vascular ischemia?

Claudication. Claudication - meaning leg, arm or organ pain during walking, stress or other condition that increase oxygen demand. That is, there is a mismatch between oxygen supply and oxygen demand. (ischemia means low blood flow, vascular means vessel.).
Depends... ...On what is ischemic. If it is bowel, it could be pain or perforation. In a leg, it could be wounds, claudication , or nothing. In the head, it could be strokes or tias.