Where does coronary artery disease originate?

CAD. Coronary artery disease, just as disease in other arteries, is the result of a long time process initiated by: 1. Genetic pre-disposition 2. Uncontrolled/untreated high blood pressure, diabetes, cholesterol/triglycerides 3. Smoking, obesity, lack of exercise, stress.
In the coronaries. When an atheromatous plaque secondary to atherosclerosis, occurs in the coronary arteries it is called coronary artery disease. Arteriosclesosis affects all the arterial system. The location of the lesions is unique to the individual.