6 doctors weighed in:
What happens during coronary artery disease?
6 doctors weighed in

Dr. Milton Alvis Jr
Preventive Medicine
2 doctors agree
In brief: AtherosclerosisClots
The key issue is atherosclerosis: accumulation of white blood cells in the walls of arteries, typically starts in childhood & is primarily driven by lipoproteins (proteins which transport fat in the water outside cells) is dominant human behavior yet is typically ignored for decades because it remains asymptomatic until plaque ruptures release debris, triggers clots & suddenly blocks blood flow.

In brief: AtherosclerosisClots
The key issue is atherosclerosis: accumulation of white blood cells in the walls of arteries, typically starts in childhood & is primarily driven by lipoproteins (proteins which transport fat in the water outside cells) is dominant human behavior yet is typically ignored for decades because it remains asymptomatic until plaque ruptures release debris, triggers clots & suddenly blocks blood flow.
Dr. Milton Alvis Jr
Dr. Milton Alvis Jr
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1 comment
Dr. Milton Alvis Jr
The idea that atherosclerosis results in artery narrowing (plumbing view) was long promoted based on the WBC accumulation being between the arterial wall muscle & endothelium combined with assumptions that angiography would show the problem (it does not). However, these ideas inconsistent with long standing observations of what actually happens. Reality: arteries enlarge at ~all plaque locations.
Dr. Louis Grenzer
Internal Medicine - Cardiology
2 doctors agree
In brief: Blockage
Plaque builds up in the wall of the artery and can cause the artery to get gradually more narrow.
If the plaque ruptures the artery can suddenly get completely blocked. The artery blockage can cause chest pain on exertion or even a heart attack resulting in permanent damage to the heart muscle.

In brief: Blockage
Plaque builds up in the wall of the artery and can cause the artery to get gradually more narrow.
If the plaque ruptures the artery can suddenly get completely blocked. The artery blockage can cause chest pain on exertion or even a heart attack resulting in permanent damage to the heart muscle.
Dr. Louis Grenzer
Dr. Louis Grenzer
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