Cholesterol . Atherosclerosis occurs when cholesterol is deposited into the walls of blood vessels, usually due to dietary issues or minor trauma. This is followed by the deposition of calcium, giving rise to obstructive lesions or plaques. Controlling cholesterol levels will aide in slowing progression, but will not lead to regression.
Wester lifestyle. Coronary artery disease is largely a disease of western civilization. As countries become more affluent, they exercise less, consume a diet with higher fat content, and gain weight. The prevalence of diabetes mellitus and coronary artery disease increases. Thus, coronary disease will become more frequent emerging countries such as india and china.