5 doctors weighed in:

What causes atherosclerosis?

5 doctors weighed in
Dr. William Cromwell
Clinical Lipidology
2 doctors agree

In brief: Multiple Factors

Atherosclerosis, also known as “hardening of the arteries”, occurs when areas of the artery wall thicken in response to either increased modifiable (high LDL particle levels, smoking or high blood pressure )and non-modifiable (genetics, age, gender) risk factors.
Over time, areas of focal thickening may grow into a larger lesion called a “plaque" that can limit blood flow through the vessel.

In brief: Multiple Factors

Atherosclerosis, also known as “hardening of the arteries”, occurs when areas of the artery wall thicken in response to either increased modifiable (high LDL particle levels, smoking or high blood pressure )and non-modifiable (genetics, age, gender) risk factors.
Over time, areas of focal thickening may grow into a larger lesion called a “plaque" that can limit blood flow through the vessel.
Dr. William Cromwell
Dr. William Cromwell
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1 comment
Dr. Milton Alvis Jr
The above illustration, ? picked by healthtap, typical of many misleading medical illustrations. It shows plaque narrowing a constant sized tube; BOGUS. Reality: plaque is in artery walls & walls enlarge at plaque locations, opening does not change, thus no symptoms. It is endothelial rupture and luminal clots which SUDDENLY create problems: http://www.nejm.org/doi/full/10.1056/NEJM198705283162204
Dr. Jerry Routh
Internal Medicine
1 doctor agrees

In brief: Cholesterol Plaque

Atherosclerosis is the build up of cholesterol and calcium plaque in the arteries of the body.
It is due to injury of the artery wall and inflammation which attracts blood cells which promote cholesterol deposition in the arteries. Known conditions which are associated with atherosclerosis include family history, smoking, hypertension, diabetes, elevated cholesterol/ldl or low hdl, and age.

In brief: Cholesterol Plaque

Atherosclerosis is the build up of cholesterol and calcium plaque in the arteries of the body.
It is due to injury of the artery wall and inflammation which attracts blood cells which promote cholesterol deposition in the arteries. Known conditions which are associated with atherosclerosis include family history, smoking, hypertension, diabetes, elevated cholesterol/ldl or low hdl, and age.
Dr. Jerry Routh
Dr. Jerry Routh
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Dr. Milton Alvis Jr
Preventive Medicine

In brief: White Blood Cells

An accumulation of white blood cells, mostly macrophages (called monocytes, one of 5 white blood cell types), which have invaded into the walls of the blood vessel to remove low density lipoprotein (fat carrying protein) particles.
Macrophages die if overwhelmed with LDL & cannot export their ingested fat into high density lipoprotein particles. Cholesterol not best focus. Otherwise largely agree.

In brief: White Blood Cells

An accumulation of white blood cells, mostly macrophages (called monocytes, one of 5 white blood cell types), which have invaded into the walls of the blood vessel to remove low density lipoprotein (fat carrying protein) particles.
Macrophages die if overwhelmed with LDL & cannot export their ingested fat into high density lipoprotein particles. Cholesterol not best focus. Otherwise largely agree.
Dr. Milton Alvis Jr
Dr. Milton Alvis Jr
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