5 doctors weighed in:
What is the difference between the stage and the grade of lung cancer?
5 doctors weighed in

Dr. Ritesh Rathore
Internal Medicine - Hematology & Oncology
1 doctor agrees
In brief: A lot
Stage refers to extent of cancer: generally stage 1 & 2 are early cancers; stage 3 involves spread to the nodes or structures in the middle of the chest; stage 4 involves spread to both lungs or other organs.
Grade refers to the degree of abnormal appearance of the cancer when seen under the microscope- usually grades range from 1-3.

In brief: A lot
Stage refers to extent of cancer: generally stage 1 & 2 are early cancers; stage 3 involves spread to the nodes or structures in the middle of the chest; stage 4 involves spread to both lungs or other organs.
Grade refers to the degree of abnormal appearance of the cancer when seen under the microscope- usually grades range from 1-3.
Dr. Ritesh Rathore
Dr. Ritesh Rathore
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1 comment
Dr. Michael Thompson
I agree. Further, you can have a high grade (micro), low stage cancer (eg breast cancer) as well as a low grade, high stage cancer (eg, indolent lymphoma). Both grade and stage are important prognostic factors, but very different features of the cancer.
Dr. Mitchell Kamrava
Radiation Oncology
1 doctor agrees
In brief: Refer to diff things
Stage refers to the extent of the disease.
It includes the size of the tumor (t stage), whether lymph nodes are involved (n stage), and whether it has spread to other sites of the body (m stage). The tnm stages are put together to give an overall stage of i-iv. Grade refers to what the tumor cells look like under the microscope and are usually graded as low, intermediate, and high.

In brief: Refer to diff things
Stage refers to the extent of the disease.
It includes the size of the tumor (t stage), whether lymph nodes are involved (n stage), and whether it has spread to other sites of the body (m stage). The tnm stages are put together to give an overall stage of i-iv. Grade refers to what the tumor cells look like under the microscope and are usually graded as low, intermediate, and high.
Dr. Mitchell Kamrava
Dr. Mitchell Kamrava
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1 comment
Dr. Reza Shirazi
Grade: how aggressive the cells are behaving when examined under the microscope. Staging as Mitch described helps us in predicting prognosis and designing appropriate treatment
Dr. David Cooke
Surgery - Thoracic
In brief: Difference
Stage refers to the size and invasiveness of a tumor (t) involvement of lymph nodes (n) and evidence of metastasis (m).
Grade refers how organized or differentiated a tumor is as it looks underneath a microscope.

In brief: Difference
Stage refers to the size and invasiveness of a tumor (t) involvement of lymph nodes (n) and evidence of metastasis (m).
Grade refers how organized or differentiated a tumor is as it looks underneath a microscope.
Dr. David Cooke
Dr. David Cooke
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