The (mostly) permanent side effects on the brain, affect those areas where serotonin is important in the brain, including the anterior lobes, and hypothalamus, areas closely connected to personality, and the experience of anxiety
belomgs to the class of benzodiazepines, which are commonly used to relieve anxiety, but are well known to have long term mood
altering side effects (major depression
is an analgesic
, and has effects on dopamin release in the brain and peripheral nervous system
Brain physiology and chemistry is very sensitive, and largely unknown. In my opinion the use of mdmd is hazardous at best, and the long term side effects on the brain are not beneficial. Combining mdma with any other mood altering drugs is even more hazardous, and may result in fatal consequences.