Psoriasis treatments I have had active psoriasis for over 40 years. I have used every possible over-the-counter treatment, including coal tar cream. Everything seems to work for a while, then becomes ineffective. I am leery of internal medications as I a

Depends . Depends a bit on location and how widespread your psoriasis is. Topical options include steroid creams, vit d derivatives (dovonex and vectical), salicylic acid and coal tar preparations. Sometimes i inject a diluted steroid into specific lesions with good results. There are some biologic therapies such as enbrel, humira, and stelara (ustekinumab) that work well for widespread cases (check out the link below for more information). I hope that helps.