My wife noticed blood while attempting a bowel movement. No spool, only blood. This happened last week as well. What to do?

Blood. Blood from the bowel needs to be evaluated by colonoscopy. It could be something as benign as hemorrhoids or something as serious as a tumor. Infections and inflammatory conditions are in the mix as well. She should start taking a stool softener now, and stop taking Aspirin and other agents that thin the blood, and call her doctor for referral to a gastroenterilogist.