8 doctors weighed in:
Does transposition of the great vessels happen because of genetics?
8 doctors weighed in

Dr. Richard Roberts
Clinical Genetics
5 doctors agree
In brief: Yes and no
There are many genetic syndromes in which a cardiac malformation occurs, including transposition.
However, there are other causes as well, such as the fetal effects of maternal diabetes, exposure to substances which can cause birth defects, and reduced folic acid in pregnancy. There are unknown patterns of malformations which we do not understand--heart defects with renal, ear, and vertebral.

In brief: Yes and no
There are many genetic syndromes in which a cardiac malformation occurs, including transposition.
However, there are other causes as well, such as the fetal effects of maternal diabetes, exposure to substances which can cause birth defects, and reduced folic acid in pregnancy. There are unknown patterns of malformations which we do not understand--heart defects with renal, ear, and vertebral.
Dr. Richard Roberts
Dr. Richard Roberts
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1 comment
Dr. Richard Roberts
Prospecdtive study of 100 IDDM babies-1% had D-TGA. d-TGA cases,-pf 369 sibs, 1 had a heart defect (0.27%). 50 sibs of l-TGA-1 sib with a heart defect (2%). Heart defects in 2 of 143 (1.4%). Sibs of a complex TGA, and 1 of 50 (2%) sibs of asplenia with TCA. Many genes are now known, 1 causing impaired intellect. Deletion at 22q11.2. Genetic analysis and counseling for recurrence risk indicated
Dr. Jay Park
Pediatrics
1 doctor agrees
In brief: No
Random occurrence.

In brief: No
Random occurrence.
Dr. Jay Park
Dr. Jay Park
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1 comment
Dr. Richard Roberts
Advances have identified many causative genes, as well as maternal diabetes epigenetic effects. See http://www.ncbi.nlm.nih.gov/pubmed/8957507 http://omim.org/entry/608808 http://www.ncbi.nlm.nih.gov/pubmed/11257060 http://www.ncbi.nlm.nih.gov/pubmed/26064504 http://www.ncbi.nlm.nih.gov/pubmed/14648003 http://omim.org/entry/208530
Dr. Barton Cook
Pediatrics - Cardiology
In brief: No
Transposition is one of the only congenital heart defects that has no increased risk of recurrence in families.

In brief: No
Transposition is one of the only congenital heart defects that has no increased risk of recurrence in families.
Dr. Barton Cook
Dr. Barton Cook
Thank
1 comment
Dr. Richard Roberts
Advances have identified many causative genes, as well as maternal diabetes epigenetic effects. See http://www.ncbi.nlm.nih.gov/pubmed/8957507 http://omim.org/entry/608808 http://www.ncbi.nlm.nih.gov/pubmed/11257060 http://www.ncbi.nlm.nih.gov/pubmed/26064504 http://www.ncbi.nlm.nih.gov/pubmed/14648003 http://omim.org/entry/208530
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