Does provigyl contain sulfur I am allergic to sulfur drugs and I have been on provigyl for years but now developing blisters on my hands

No. Most people are allergic to sulphonamides, or sulfa medications, not medications that contain sulfur, which is different. Provigil does not contain a sulfa group and so would not be related to your sulfa allergy. However, very severe rashes have been associated with provigil, and this could be a different type of reaction. You should see your doctor immediately.
Need . Need more information. Are you on any other drugs? Have you had any other exposures? Would consult a dermatologist first.