10 doctors weighed in:
Are there medications that can be combined with deep brain stimulation for Parkinson's to increase the treatment's effectiveness?
10 doctors weighed in

5 doctors agree
In brief: Medication benefits
Dopamine meds for physical symptoms: first, Azilect (mao-b inhibitor) & then Dopamine agonists (requipmirapex/neupro).
Last add sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx watching for side effects. For dementia: Namenda plus Exelon or aricept. For psychosis: seroquel. For sleepiness/fatigue: nuvigil. For insomnia: Clonazepam or seroquel. For depression/anxiety: Lexapro or Effexor :).

In brief: Medication benefits
Dopamine meds for physical symptoms: first, Azilect (mao-b inhibitor) & then Dopamine agonists (requipmirapex/neupro).
Last add sinemet +/- Comtan (stalevo (carbidopa and levodopa and entacapone) is both together). Tailor rx watching for side effects. For dementia: Namenda plus Exelon or aricept. For psychosis: seroquel. For sleepiness/fatigue: nuvigil. For insomnia: Clonazepam or seroquel. For depression/anxiety: Lexapro or Effexor :).
Dr. Robert Hutchman
Dr. Robert Hutchman
Thank
5 doctors agree
In brief: DBS Benefits
Deep brain stimulation therapy of the stn (sub-thalamic nucleus) or gpi (globus pallidus interna) can greatly improve "on" time (good function with minimized symptoms) & greatly reduce dyskinesia (twisting, writhing, jerking movements during "on" time).
Good candidates must be not demented, psychiatrically stable, & still demonstrating good symptom relief from meds, but with inconsistent results.

In brief: DBS Benefits
Deep brain stimulation therapy of the stn (sub-thalamic nucleus) or gpi (globus pallidus interna) can greatly improve "on" time (good function with minimized symptoms) & greatly reduce dyskinesia (twisting, writhing, jerking movements during "on" time).
Good candidates must be not demented, psychiatrically stable, & still demonstrating good symptom relief from meds, but with inconsistent results.
Dr. Robert Hutchman
Dr. Robert Hutchman
Thank
5 doctors agree
In brief: Yes & No
Meds won't increase the effectiveness of dbs per se, but they can produce additive benefit in resolving physical symptoms.
Dbs only treats the physical symptoms. However, meds can also help address dementia, depression, anxiety, psychosis, orthostatic hypotension, erectile dysfunction, excess daytime sleepiness, fatigue, insomnia, etc. I'll add other responses for this ? To explain this further :).

In brief: Yes & No
Meds won't increase the effectiveness of dbs per se, but they can produce additive benefit in resolving physical symptoms.
Dbs only treats the physical symptoms. However, meds can also help address dementia, depression, anxiety, psychosis, orthostatic hypotension, erectile dysfunction, excess daytime sleepiness, fatigue, insomnia, etc. I'll add other responses for this ? To explain this further :).
Dr. Robert Hutchman
Dr. Robert Hutchman
Thank
Dr. Steven Giannotta
Neurosurgery
4 doctors agree
In brief: Yes
Dbs usually helps the tremor.
The rigidity and slow movements are still best treated by the medications, so many patients get both.

In brief: Yes
Dbs usually helps the tremor.
The rigidity and slow movements are still best treated by the medications, so many patients get both.
Dr. Steven Giannotta
Dr. Steven Giannotta
Thank
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