Any suggestions, concerned grandparent have a 16 yo g-son weighing approx 365lbs, 6'1", (autism spectrum disorder, add, etc) does mixed martial arts w/wrestling m-w-f equalling 5 hours wkly, also plays soccer t-thu with warm up excerise plays game for app

Nutrient dense foods. Eat foods that are nutrient dense (like meat, fish, poultry, eggs, cheese, low starch vegatables and water) avoid foods that are not nutrient dense (like starches and sugars, including fruit) nutrient dense foods will increase your basal metabolic rate. On the other hand, starches and sugars impair thyroid metabolism via affects on your liver (which helps activate thyroid hormone).
His Body Mass Index, If 16 yrs., 0 mos. With ht. 73"'& wt. 365 lbs., is 48.26, in the morbidly obese range. A bmi of 27.51 is 95th%ile for him. Kids with autism often self-limit their diets, & eat only carbohydrates & high-fat foods & no green vegetables. Rec: blood tests for metabolic syndrome, diabetes, & genetic disorders (comparative genomic hybridization), a sleep study for apnea & review of his medications.
Diet . Diet is essential when trying to loose weight. If he only eats in the evenings and on weekends he is starving himself in a sense. Think of it like this, the body constantly nedds fuel (in the form of food) the body uses this fuel throughout the day, especially if one is working out as much as your grandson. If your grandson is consistently skipping breakfast and lunch, his body will think it's starving, and in turn will hold on to all the food he intakes(night time meals.) the body is basically saving this food up in the form of fat stores because it does not know when it will get more fuel. Over time these fat stores build up and so does your grandson's weight, regardless of the intense work outs. The best way to tackle this problem is to have your grandson eat 6 healthy small to medium sized meals a day. This will help boost his metabolism and get those fat stores burning! in addition you may consult a nutritionist for a detailed diet plan an further explanation/insight. Good luck.
What's really wrong? This is morbid obesity that will ruin the quality of his life, whatever he really has. You'll need to tell me what "autism / add" really are, but I am concerned that junior may have prader-willi or another syndromic cause of morbid overeating. There's no one-size-fits-all answer, but there's new work on specific rx for prader-willi hyperphagia; bariatric surgery might be a consideration.