Is there a single disease that could cause tiredness, a lot of weight loss, nausea, and bloody urine?

Yes. Need medical evaluation to make sure there is no lifethreating condition like cancer, infection, stones.
No. There are a number of conditions that may lead to this combination of symptoms and signs. The most worrisome would be some sort of maligancy in the genito-urinary tract. This could include kidney, ureter, bladder (for both men and women) and prostate (in men). Any patient with these symptoms should see a physician urgently so that a diagnosis may be made and treatment may begin.