Various options. There are a number of factors, including the original pathology, how quickly you recurred, the type of recurrence, etc. In my practice, I will often give a second round of bcg other options include: bcg plus interferon mitomycin c thiotepa valrubicin and of course cystectomy.
BCG plus interferon. There is evidence that BCG plus ifn can salvage or successfully treat people who have failed BCG alone. Also, your overall risk depends on the grade and stage of your original cancer. If it is low grade low stage, then the overall risk is quite different than patient with high grade superficial bladder cancer.
I have had 4 turb's for non invasive bladder cancer and have decided not to have BCG treatments. Can I just have my bladder removed?
Sometimes necessary. Depends on grade (aggressive nature) of tumor. For those with low grade disease, turb often is curative. However, for high grade disease and recurrent disease resection alone is not enough, and we recommend bcg. For someone with recurrent high grade disease, some urologist may advocate for early cystectomy (bladder removal) but many will advocate a course of bcg. Was yours low or high grade?
Not standard. Local bladder therapy such as BCG and others can put off the need for bladder removal for quite a period. Bladder removal can be done but urine pathway reconstruction will need to be surgically done too. Your urologist can discuss other local treatment drugs besides bcg. Finally, many centers are looking at robotic bladder surgery.
Be careful what you. Ask for, you might get it. Cystectomy or prostocytectomy, with urinary diversion is something to adapt to when you need it. Deciding not to have BCG and opting for cyctectomy sounds petulant. Discuss this with a few urologists, experienced with both, and air your reasons for spurning the relatively benign BCG for the more than you know cyctectomy.
I failed interferon treatment and BCG treatment for bladder cancer. Is surgery the only option left?
Probably best option. If you have failed tretament with BCG and interferon, some patients may reposnd to treatment with valstar (valrubicin). However, depending on the specifics of your bladder cancer, cystectomy and urinary diversion may be your best option. You should discuss this with your urologist.
Not as easy to answe. Some people have tried other intravesical therapies like Mitomycin or valstar (valrubicin) that now is indicated for BCG failure. The problem is it is important to know how many and time between recurrences and how much involvement in your bladder. Multifocal recurrent disease is not a good prognosis and you should not wait since bladder cancer will progress. If you are healthy, you should consider cystectomy.
BCG treatment to reduce recurrence rate for bladder cancer. I have 2 nd bladder tumor after 5 year of the first. This mean the BCG work or not?
Yes it works. In selective oatients, Intra bladder installation of BCG is very effective in 70% of time for non invasive bladder cancers. Speak to your doctor if you are a candidate or not.
I was diagnosed with bladder cancer in 1980 and one treatment with BCG 1990, since then one tumor and haven't had tumor since 2000. Do I need a cysto?
I'd do it. The altered urothelium in which bladder cancer arises is never really returned to normal. I'm glad you've gotten good results so far.
Maybe. I think you can avoid a cystoscopy if you do not have any symptoms and your urinalysis is normal. Also, I would base it on your original pathology. If it was a low grade tumor you can hold off. You could do a urine cytology, urine sample looking for abnormal cells, to insure there is no evidence of a more aggressive tumor.
Localized immune rea. Ction. If a person is immunized with BCG (a modified tuberculosis organism) re-exposure to BCG induces a local cellular immune response. If BCG is instilled into the bladder of person with bladder cancer, after prior sensitization to bcg, the local cellular immune response may destroy tumor cells.
Immune system based. Bcg is a weakened bacteria in the family of germs that causes tuberculosis. In bladder cancer, it is believed that interactions of BCG and molecules in the cellular structure of the bladder itself induces an immune-mediated response which can cause superficial cancers of the bladder to regress and can delay or prevent recurrence in many cases. It is usually given weekly for 6 weeks to start.
No. Treatment with BCG is a form of localized immunotherapy for bladder cancer but it is not chemotherapy. It involves placement of a medicine into the bladder that helps one's own immune system fight the cancer.
No. Bcg is a topical therapy that is essentially a type of immune based therapy applied only to bladder cells. Traditional chemotherapy is given intravenously and thus all body cells are exposed. Some chemotherapy drugs can be given topically like BCG and probably exert their effect via typical cancer cell-killing compared to immune stimulating effects of BCG similarly administered.
For a 70-year-old man who was recently diagnosed with bladder cancer, is BCG a reasonable 1st treatment?
Maybe. Bcg is a first good step but depends on the biopsy specimen. Bcg is standard treatment for certain types of bladder cancer and if the patient meets those criteria, then it is a good first step. It is not necessarily dependent on age.
Depends. Bladder cancer should first be removed as much as possible through a scope placed through the penis and urethra into the bladder. For small tumors that have not grown into the muscle, either bcg or chemotherapy placed directly in the bladder is usually recommended to try to kill any remaining microscopic cells and minimize the risk of recurrence. More advanced tumors need different treatment.