Stem cell apheresis for bone marrow transplant? How does this work and is it safe? I thought bone marrow stem cells were inside your bones, so how can you collect them from your blood? Also, can your body make more bone marrow without the stem cells?

Most . Most bone marrow stem cells are inside you bones, some are floating around. When given a medication/natural substance called gcsf or Neupogen more stem cells are found in the peripheral blood. These can be removed by a machine that filters your blood. An IV is placed in two places, your blood is removed, filtered and returned. You are left with stem cells so you too continue to make blood.
Peripheral . Peripheral blood stem cell apheresis is the standard methodology for collecting hematopoietic stem cells to perform a hematopoietic stem cell transplant (alternative name: peripheral blood stem cell transplant, bone marrow transplant (using similar cells collected from bone marrow). This is a relatively safe procedure. Over 14 million people world wide have agreed to participate in donating peripheral blood stem cells for patients who need to undergo a bone marrow transplant/hematopoietic stem cell transplant procedure for leukemia and other blood cancers. Siblings who share a similar immune system type may also serve as a donor for their brother/sister who need to undergo a transplant. Apheresis is generally a safe procedure. Donation of hematopoietic stem cells does not have long term adverse effects based upon evaluation of thousands of donors during the past several decades. For a "normal donor", the procedure requires an initial physical examination and blood work. The procedure requires several days of receiving a "growth factor" such as Neupogen (g-csf) to stimulate the donor's bone marrow hematopoietic stem cells. On the day of collection, the donor undergoes apheresis collection. The procedure is similar to the donation of platelets in that the person sits in a chair next to an apheresis machine, and over about 3-4 hours the stem cells are removed from the blood. This is often performed in the outpatient setting. For more information, contact www.Marrow.Org and be the match at the national marrow donor program.

Related Questions

Can stem cells be used as a substitute for a bone marrow transplant?

Let me clarify. Stem cells are the mother cells. For blood formation the stem cells reside in the bone marrow but they also circulate in the blood. In the old days we took the stem cells out of the bone marrow with needles. Now we can spin the blood(from a vein) and take th stem cells out and use them for transplants to make new blood. This is stricly for creating new blood cells. But each organ has its stem cell. Read more...

Could stem cells prevent need for a bone marrow transplant?

NO. Bone marrow transplant is a stem cell procedure. This can be your own bone marrow stem cells, a family member or match for bone marrow or embryonic stem cells. Read more...

Can stem cells prevent the future need for a bone marrow transplant?

They are the same. When someone gets a bone marrow transplant (also called a stem cell transplant) what they are given from their donor are hematopoietic (blood forming) stem cells. So getting stem cells is what happens during a bone marrow/stem cell transplant. Read more...

Why are umbilical cord stem cells sometimes uses along with donor cells in an allogeneic bone marrow transplant?

One of the other. Stem cells can be obtained from 3 different sources: from Bone marrow of the Donor, blood of the donor or stem cells from umbilical cord. But we have to give an adequate number(Dose) of stem cells in order to have full protection. So combining them may only be needed because of inadequate number of stem cells from one of the sources. Read more...

Is a stem cell transplant better than a bone marrow transplant from an identical twin with regard to a.L.L leukaemia?

Either may be helpfu. Both can offer cells which can potentially be helpful. Peripheral stem cell collection may be an easier procedure for the donor, rather than sequential bone marrow aspirates from the donor. Depending on the acuity of the patient, the hematologist/oncologist may want to discuss this with the donor. Read more...