Severe depression. What can I do? I just want to feel good again. (inside that is). I suffer chronic back pain from inneffective surgeries and have t-cell lymphoma. I have tried antidepressants (zoloft, paxil, Lexapro and pristiq).None of these have helped. Can
A . A combination of cognitive behavioral therapy and anti depressants is an effective treatment strategy. There are other anti depressants with a different mechanism of action that could be tried- eg: tricyclic anti depressants (nortriptyline), mirtazapine, MAO inhibitors.The treatment could also be augmented with medications in the class of Abilify (aripiprazole) , seroquel etc. If nothing else works , electroconvulsive therapy is a safe and effective treatment option.Please talk to your psychiatrist and hope you get well soon.