Are bladder biopsies very painful?

See below. If the bladder biopsy is done in the office while you are awake, one expect a brief pain when the biopsy is taken and a similar sensation if cautery is used at the biopsy site to prevent/control any bleeding. After the biopsy, depending on the individual and extent of the biopsy, one can anticipate a variable degree of urinary frequency, urgency, burning, and blood in the urine for a few days. .
No. Bladder biopsies are generally an office procedure. It is performed by placing a telescope into the bladder and removing a small portion for pathological examination to determine if there is cancer present. It can safely be performed in the office with minimal discomfort during the procedure. There will be some mild burning after the procedure which will usually resolve in a few days.