4 doctors weighed in:

I have never understood how ld50 is very confidence inducing? Has the medical profession ever considered raising that standard?

4 doctors weighed in
Dr. Donald Stewart
Family Medicine
2 doctors agree

In brief: The

The ld50, which is the dose of a substance that will result in death of 50% of the people who take it, is not really a medical term. It is a term from the science of toxicology.
In medical use, it is a way judging the relative safety of a medication. Generally, a physician would want to prescribe a medication with a therapeutic dose that was as much lower than its ld50 as possible.. Most substances, even water, can kill people if taken at a high enough dose. The ld50 is simply a way of looking at the relative safety, or danger, of a substance.

In brief: The

The ld50, which is the dose of a substance that will result in death of 50% of the people who take it, is not really a medical term. It is a term from the science of toxicology.
In medical use, it is a way judging the relative safety of a medication. Generally, a physician would want to prescribe a medication with a therapeutic dose that was as much lower than its ld50 as possible.. Most substances, even water, can kill people if taken at a high enough dose. The ld50 is simply a way of looking at the relative safety, or danger, of a substance.
Dr. Donald Stewart
Dr. Donald Stewart
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1 comment
Dr. Ed Friedlander
The LD50 is of course only one of a host of numbers we look at to determine whether something is safe. I appreciate your question and your concern about safety of the medicines you take. It would be misleading at best to suggest that LD50 is central to anybody's calculations of an appropriate dose for a medication.
Dr. Dan Fisher
Internal Medicine

In brief: See below.

We have all grown accustomed to using it as it is.
It works clinically and "better" is not always better. For example would an ld 20 or ld 90 be more useful? There is no incentive to change because it is good enough.

In brief: See below.

We have all grown accustomed to using it as it is.
It works clinically and "better" is not always better. For example would an ld 20 or ld 90 be more useful? There is no incentive to change because it is good enough.
Dr. Dan Fisher
Dr. Dan Fisher
Thank
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