7 doctors weighed in:
How does a severe crush injury lead to ards?
7 doctors weighed in

Dr. Michael DePietro
Internal Medicine - Pulmonary Critical Care
2 doctors agree
In brief: Inflammation
Patients who are critically ill get inflammation throughout the body that affects multiple organs.
When the lung is affected it becomes filled with fluid, stiff and has difficulty doing its job of getting oxygen into the body, and carbon dioxide ( our waste gas) out. This is called ards.. In traumatic injuries/ crush, material leaked from the damaged tissue can act as the inflammatory trigger.

In brief: Inflammation
Patients who are critically ill get inflammation throughout the body that affects multiple organs.
When the lung is affected it becomes filled with fluid, stiff and has difficulty doing its job of getting oxygen into the body, and carbon dioxide ( our waste gas) out. This is called ards.. In traumatic injuries/ crush, material leaked from the damaged tissue can act as the inflammatory trigger.
Dr. Michael DePietro
Dr. Michael DePietro
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Dr. William Walsh
Addiction Medicine
1 doctor agrees
In brief: SIRS
Crush injuries start the inflammatory cascade that leads to a cytokine storm throughout the body; it is not clear which mediator is more important in crush syndrome leading to ards, but tissue ischemia or necrosis are necessary before you will see ards.
The inflammatory cascade usually does not just injure the lungs, but the heart, liver, and kidneys are often affected as well.

In brief: SIRS
Crush injuries start the inflammatory cascade that leads to a cytokine storm throughout the body; it is not clear which mediator is more important in crush syndrome leading to ards, but tissue ischemia or necrosis are necessary before you will see ards.
The inflammatory cascade usually does not just injure the lungs, but the heart, liver, and kidneys are often affected as well.
Dr. William Walsh
Dr. William Walsh
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Dr. Gutti Rao
Internal Medicine - Hospital-based practice
In brief: Yes
Severe trauma can precipitate ards.

In brief: Yes
Severe trauma can precipitate ards.
Dr. Gutti Rao
Dr. Gutti Rao
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Dr. Vasu Brown
Wound care
In brief: Local muscle injury
Direct pressure on muscle cells: the direct pressure of the crush injury causes the muscle cells to become ischemic.
The cells then switch to anaerobic metabolism, generating large amounts of lactic acid. Prolonged ischemia then causes the cell membranes to leak. Muscle can only withstand 4 hours ischemia ( without blood), there is also direct pressure due to crush (earth quakes).

In brief: Local muscle injury
Direct pressure on muscle cells: the direct pressure of the crush injury causes the muscle cells to become ischemic.
The cells then switch to anaerobic metabolism, generating large amounts of lactic acid. Prolonged ischemia then causes the cell membranes to leak. Muscle can only withstand 4 hours ischemia ( without blood), there is also direct pressure due to crush (earth quakes).
Dr. Vasu Brown
Dr. Vasu Brown
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1 comment
Dr. William Walsh
More by causing systemic inflammation (SIRS) that can lead to direct lung injury. Lactic acid has little to do with the onset of ARDS, but does rise stoichiometrically with the local tissue injury.
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Board Certified, Internal Medicine - Pulmonology
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