Is it normal to have side effects taking new osteoporosis meds?

Uncommon. Side effects from osteoporosis drugs are generally not common. Symptoms of flu may occur in about 40% of patients who receive their first intravenous infusion of Reclast (zoledronic acid) heartburn occurs in 5-10% of patients taking bisphosphonate pills. Estrogen may cause wight gain, breast tenderness and blood clots.